Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 99212..99855 Replicon plasmid pKBSW50i-A
Accession NZ_CP110259
Organism Escherichia albertii strain KBSW50i

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag N6N69_RS23065 Protein ID WP_096306143.1
Coordinates 99439..99855 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag N6N69_RS23060 Protein ID WP_096306144.1
Coordinates 99212..99442 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6N69_RS23035 (95282) 95282..95809 - 528 WP_000203268.1 colicin B immunity protein -
N6N69_RS23040 (96052) 96052..96867 + 816 WP_000449473.1 lipid II-degrading bacteriocin colicin M -
N6N69_RS23045 (96917) 96917..97270 - 354 WP_000864812.1 colicin M immunity protein -
N6N69_RS23050 (97443) 97443..98225 - 783 WP_024127883.1 site-specific integrase -
N6N69_RS23055 (98227) 98227..98640 - 414 WP_024241438.1 hypothetical protein -
N6N69_RS23060 (99212) 99212..99442 + 231 WP_096306144.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
N6N69_RS23065 (99439) 99439..99855 + 417 WP_096306143.1 type II toxin-antitoxin system VapC family toxin Toxin
N6N69_RS23070 (99930) 99930..101495 + 1566 WP_001128474.1 AAA family ATPase -
N6N69_RS23075 (101480) 101480..102502 + 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iutA / iucD / iucC / iucB / iucA 1..125950 125950
- flank IS/Tn - - 102756..103133 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15102.56 Da        Isoelectric Point: 7.2929

>T263499 WP_096306143.1 NZ_CP110259:99439-99855 [Escherichia albertii]
VNKIYMLDTNICSFIMREQPKAVLKHLEQAVLCGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8833.96 Da        Isoelectric Point: 4.3775

>AT263499 WP_096306144.1 NZ_CP110259:99212-99442 [Escherichia albertii]
MRTVSIFRNGNNRAIRLPRDLDFEGVSELEIIREGDSIILRPVRPTWSSFLELEKADPDFMTEREDVVSDEGRINL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References