Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3403715..3404333 Replicon chromosome
Accession NZ_CP110258
Organism Escherichia albertii strain KBSW50i

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag N6N69_RS16620 Protein ID WP_001280991.1
Coordinates 3404115..3404333 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag N6N69_RS16615 Protein ID WP_000344798.1
Coordinates 3403715..3404089 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6N69_RS16605 (3398795) 3398795..3399988 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N6N69_RS16610 (3400011) 3400011..3403160 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
N6N69_RS16615 (3403715) 3403715..3404089 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
N6N69_RS16620 (3404115) 3404115..3404333 + 219 WP_001280991.1 HHA domain-containing protein Toxin
N6N69_RS16625 (3404510) 3404510..3405067 + 558 WP_000093561.1 maltose O-acetyltransferase -
N6N69_RS16630 (3405175) 3405175..3405645 + 471 WP_059224581.1 YlaC family protein -
N6N69_RS16635 (3405809) 3405809..3407359 + 1551 WP_262930572.1 EAL domain-containing protein -
N6N69_RS16640 (3407397) 3407397..3407750 - 354 WP_000878151.1 DUF1428 family protein -
N6N69_RS16650 (3408131) 3408131..3408442 + 312 WP_000409915.1 MGMT family protein -
N6N69_RS16655 (3408472) 3408472..3409044 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T263489 WP_001280991.1 NZ_CP110258:3404115-3404333 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT263489 WP_000344798.1 NZ_CP110258:3403715-3404089 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References