Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 915220..915871 Replicon chromosome
Accession NZ_CP110258
Organism Escherichia albertii strain KBSW50i

Toxin (Protein)


Gene name cptA Uniprot ID A0A8D9PM36
Locus tag N6N69_RS04495 Protein ID WP_044714929.1
Coordinates 915467..915871 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N6N69_RS04490 Protein ID WP_000354046.1
Coordinates 915220..915486 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6N69_RS04465 (910932) 910932..912365 - 1434 WP_025238420.1 6-phospho-beta-glucosidase BglA -
N6N69_RS04470 (912410) 912410..912721 + 312 WP_001182937.1 N(4)-acetylcytidine aminohydrolase -
N6N69_RS04475 (912889) 912889..913548 + 660 WP_000250281.1 hemolysin III family protein -
N6N69_RS04480 (913988) 913988..914968 - 981 WP_103053871.1 tRNA-modifying protein YgfZ -
N6N69_RS04485 (915000) 915000..915230 + 231 WP_000181267.1 hypothetical protein -
N6N69_RS04490 (915220) 915220..915486 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N6N69_RS04495 (915467) 915467..915871 + 405 WP_044714929.1 protein YgfX Toxin
N6N69_RS04500 (915910) 915910..916431 - 522 WP_044714926.1 flavodoxin FldB -
N6N69_RS04505 (916543) 916543..917439 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N6N69_RS04510 (917464) 917464..918174 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N6N69_RS04515 (918180) 918180..919913 + 1734 WP_105227436.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15835.76 Da        Isoelectric Point: 10.2082

>T263481 WP_044714929.1 NZ_CP110258:915467-915871 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLCLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT263481 WP_000354046.1 NZ_CP110258:915220-915486 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References