Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4124..4911 Replicon plasmid pZMOB04
Accession NC_017184
Organism Zymomonas mobilis subsp. mobilis ATCC 10988

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0H3G914
Locus tag ZMOB_RS09545 Protein ID WP_014466469.1
Coordinates 4417..4911 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A0H3G0U6
Locus tag ZMOB_RS09540 Protein ID WP_014466468.1
Coordinates 4124..4420 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ZMOB_RS09510 27..257 + 231 WP_012817662.1 hypothetical protein -
ZMOB_RS09515 254..634 + 381 WP_012817663.1 type II toxin-antitoxin system death-on-curing family toxin -
ZMOB_RS09520 1410..1646 + 237 WP_014466464.1 hypothetical protein -
ZMOB_RS10140 2613..2852 + 240 WP_185737979.1 hypothetical protein -
ZMOB_RS09530 2986..3246 - 261 WP_014466466.1 ribbon-helix-helix protein, CopG family -
ZMOB_RS09535 3276..3926 - 651 WP_014466467.1 AAA family ATPase -
ZMOB_RS09540 4124..4420 + 297 WP_014466468.1 DUF1778 domain-containing protein Antitoxin
ZMOB_RS09545 4417..4911 + 495 WP_014466469.1 GNAT family N-acetyltransferase Toxin
ZMOB_RS10030 4984..5747 + 764 WP_099045773.1 IS5 family transposase -
ZMOB_RS09555 5732..6049 - 318 WP_014466470.1 helix-turn-helix transcriptional regulator -
ZMOB_RS09560 6255..6563 - 309 WP_014466471.1 type II toxin-antitoxin system RelE/ParE family toxin -
ZMOB_RS09565 6547..6795 - 249 WP_041573485.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ZMOB_RS09570 7153..7578 - 426 WP_014466473.1 type II toxin-antitoxin system HicB family antitoxin -
ZMOB_RS10035 7588..7767 - 180 WP_080558567.1 type II toxin-antitoxin system HicA family toxin -
ZMOB_RS09575 7979..9484 - 1506 WP_014466475.1 helix-turn-helix domain-containing protein -
ZMOB_RS09580 9591..9842 - 252 WP_014466426.1 DUF2312 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..18461 18461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(7-97)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18083.16 Da        Isoelectric Point: 10.3343

>T26347 WP_014466469.1 NC_017184:4417-4911 [Zymomonas mobilis subsp. mobilis ATCC 10988]
VTITAPELLSPEHQVDLFQSGVKSLDLWLKKRALKNQMTGASRTFVACKNRRVMAYYALASSAITIKSAHGRFRRNMPDP
IPVVVLGRLAIDQSLHNQGVGRAMVRDAALRIIQAANTIGIRGMLVHALSDEAKSFYEHIGFEPSPIDPMMLMITLADLK
SSLD

Download         Length: 495 bp

>T26347 NC_017184:4417-4911 [Zymomonas mobilis subsp. mobilis ATCC 10988]
GTGACAATAACAGCCCCAGAATTATTATCCCCAGAACATCAAGTTGACTTATTTCAATCTGGTGTAAAGAGCCTTGATCT
ATGGCTGAAAAAGCGTGCTTTAAAAAATCAAATGACAGGAGCCTCTCGCACATTTGTAGCCTGTAAAAATCGACGGGTGA
TGGCCTATTATGCTCTGGCATCTAGCGCTATCACTATAAAATCAGCCCATGGACGATTTAGGCGTAATATGCCAGATCCT
ATTCCTGTTGTCGTTTTAGGGCGGCTTGCTATTGATCAATCTTTACATAACCAAGGCGTTGGACGAGCAATGGTAAGGGA
TGCAGCCTTAAGGATAATACAGGCAGCTAATACTATCGGCATTAGAGGTATGCTCGTTCATGCGCTATCTGATGAAGCCA
AATCTTTCTACGAACATATCGGTTTCGAACCGTCTCCAATCGACCCAATGATGTTGATGATTACATTAGCCGATTTAAAG
TCGAGCCTTGACTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11283.10 Da        Isoelectric Point: 10.1464

>AT26347 WP_014466468.1 NC_017184:4124-4420 [Zymomonas mobilis subsp. mobilis ATCC 10988]
MVATTTISSPKKREALNIRIKPEERDLIDRAAKIQRKSRTDFVLEAACRAAEEALFDQLIITVDPKAYTNFLTRLDMPPR
PNDRLQKTMQTVAPWDKL

Download         Length: 297 bp

>AT26347 NC_017184:4124-4420 [Zymomonas mobilis subsp. mobilis ATCC 10988]
ATGGTAGCCACAACAACAATATCTTCACCGAAAAAACGAGAAGCGCTGAATATTAGAATTAAACCGGAAGAACGTGATTT
AATAGATCGAGCGGCAAAAATTCAGAGAAAAAGCCGTACTGATTTTGTATTAGAGGCAGCTTGTAGGGCTGCAGAAGAAG
CACTGTTCGATCAATTAATCATTACTGTAGATCCCAAGGCCTATACTAATTTCTTAACACGCCTTGATATGCCACCACGC
CCAAATGATCGGCTGCAAAAAACCATGCAAACGGTAGCTCCGTGGGATAAGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3G914

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3G0U6

References