Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4124..4911 Replicon plasmid pZMOB04
Accession NC_017184
Organism Zymomonas mobilis subsp. mobilis ATCC 10988

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0H3G914
Locus tag ZMOB_RS09545 Protein ID WP_014466469.1
Coordinates 4417..4911 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A0H3G0U6
Locus tag ZMOB_RS09540 Protein ID WP_014466468.1
Coordinates 4124..4420 (+) Length 99 a.a.

Genomic Context

ZMOB_RS09510ZMOB_RS09515ZMOB_RS09520ZMOB_RS10140ZMOB_RS09540ZMOB_RS09545ZMOB_RS10030ZMOB_RS09530ZMOB_RS09535ZMOB_RS09555ZMOB_RS09560ZMOB_RS09565ZMOB_RS09570ZMOB_RS10035ZMOB_RS09575ZMOB_RS09580
Location: 27..257 (231 bp)
Type: Others
Protein ID: WP_012817662.1
Location: 254..634 (381 bp)
Type: Others
Protein ID: WP_012817663.1
Location: 1410..1646 (237 bp)
Type: Others
Protein ID: WP_014466464.1
Location: 2613..2852 (240 bp)
Type: Others
Protein ID: WP_185737979.1
Location: 4124..4420 (297 bp)
Type: Antitoxin
Protein ID: WP_014466468.1
Location: 4417..4911 (495 bp)
Type: Toxin
Protein ID: WP_014466469.1
Location: 4984..5747 (764 bp)
Type: Others
Protein ID: WP_099045773.1
Location: 2986..3246 (261 bp)
Type: Others
Protein ID: WP_014466466.1
Location: 3276..3926 (651 bp)
Type: Others
Protein ID: WP_014466467.1
Location: 5732..6049 (318 bp)
Type: Others
Protein ID: WP_014466470.1
Location: 6255..6563 (309 bp)
Type: Others
Protein ID: WP_014466471.1
Location: 6547..6795 (249 bp)
Type: Others
Protein ID: WP_041573485.1
Location: 7153..7578 (426 bp)
Type: Others
Protein ID: WP_014466473.1
Location: 7588..7767 (180 bp)
Type: Others
Protein ID: WP_080558567.1
Location: 7979..9484 (1506 bp)
Type: Others
Protein ID: WP_014466475.1
Location: 9591..9842 (252 bp)
Type: Others
Protein ID: WP_014466426.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ZMOB_RS0951027..257+231WP_012817662.1hypothetical protein-
ZMOB_RS09515254..634+381WP_012817663.1type II toxin-antitoxin system death-on-curing family toxin-
ZMOB_RS095201410..1646+237WP_014466464.1hypothetical protein-
ZMOB_RS101402613..2852+240WP_185737979.1hypothetical protein-
ZMOB_RS095302986..3246-261WP_014466466.1ribbon-helix-helix protein, CopG family-
ZMOB_RS095353276..3926-651WP_014466467.1AAA family ATPase-
ZMOB_RS095404124..4420+297WP_014466468.1DUF1778 domain-containing proteinAntitoxin
ZMOB_RS095454417..4911+495WP_014466469.1GNAT family N-acetyltransferaseToxin
ZMOB_RS100304984..5747+764WP_099045773.1IS5 family transposase-
ZMOB_RS095555732..6049-318WP_014466470.1helix-turn-helix transcriptional regulator-
ZMOB_RS095606255..6563-309WP_014466471.1type II toxin-antitoxin system RelE/ParE family toxin-
ZMOB_RS095656547..6795-249WP_041573485.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
ZMOB_RS095707153..7578-426WP_014466473.1type II toxin-antitoxin system HicB family antitoxin-
ZMOB_RS100357588..7767-180WP_080558567.1type II toxin-antitoxin system HicA family toxin-
ZMOB_RS095757979..9484-1506WP_014466475.1helix-turn-helix domain-containing protein-
ZMOB_RS095809591..9842-252WP_014466426.1DUF2312 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..1846118461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(7-97)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18083.16 Da        Isoelectric Point: 10.3343

>T26347 WP_014466469.1 NC_017184:4417-4911 [Zymomonas mobilis subsp. mobilis ATCC 10988]
VTITAPELLSPEHQVDLFQSGVKSLDLWLKKRALKNQMTGASRTFVACKNRRVMAYYALASSAITIKSAHGRFRRNMPDP
IPVVVLGRLAIDQSLHNQGVGRAMVRDAALRIIQAANTIGIRGMLVHALSDEAKSFYEHIGFEPSPIDPMMLMITLADLK
SSLD

Download         Length: 495 bp

>T26347 NC_017184:4417-4911 [Zymomonas mobilis subsp. mobilis ATCC 10988]
GTGACAATAACAGCCCCAGAATTATTATCCCCAGAACATCAAGTTGACTTATTTCAATCTGGTGTAAAGAGCCTTGATCT
ATGGCTGAAAAAGCGTGCTTTAAAAAATCAAATGACAGGAGCCTCTCGCACATTTGTAGCCTGTAAAAATCGACGGGTGA
TGGCCTATTATGCTCTGGCATCTAGCGCTATCACTATAAAATCAGCCCATGGACGATTTAGGCGTAATATGCCAGATCCT
ATTCCTGTTGTCGTTTTAGGGCGGCTTGCTATTGATCAATCTTTACATAACCAAGGCGTTGGACGAGCAATGGTAAGGGA
TGCAGCCTTAAGGATAATACAGGCAGCTAATACTATCGGCATTAGAGGTATGCTCGTTCATGCGCTATCTGATGAAGCCA
AATCTTTCTACGAACATATCGGTTTCGAACCGTCTCCAATCGACCCAATGATGTTGATGATTACATTAGCCGATTTAAAG
TCGAGCCTTGACTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11283.10 Da        Isoelectric Point: 10.1464

>AT26347 WP_014466468.1 NC_017184:4124-4420 [Zymomonas mobilis subsp. mobilis ATCC 10988]
MVATTTISSPKKREALNIRIKPEERDLIDRAAKIQRKSRTDFVLEAACRAAEEALFDQLIITVDPKAYTNFLTRLDMPPR
PNDRLQKTMQTVAPWDKL

Download         Length: 297 bp

>AT26347 NC_017184:4124-4420 [Zymomonas mobilis subsp. mobilis ATCC 10988]
ATGGTAGCCACAACAACAATATCTTCACCGAAAAAACGAGAAGCGCTGAATATTAGAATTAAACCGGAAGAACGTGATTT
AATAGATCGAGCGGCAAAAATTCAGAGAAAAAGCCGTACTGATTTTGTATTAGAGGCAGCTTGTAGGGCTGCAGAAGAAG
CACTGTTCGATCAATTAATCATTACTGTAGATCCCAAGGCCTATACTAATTTCTTAACACGCCTTGATATGCCACCACGC
CCAAATGATCGGCTGCAAAAAACCATGCAAACGGTAGCTCCGTGGGATAAGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3G914

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3G0U6

References