Detailed information of TA system TA026346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 15455..15977
• Replicon: plasmid pZMOB01
• Accession: NC_017180
• Organism: Zymomonas mobilis subsp. mobilis ATCC 10988

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ZMOB_RS09980
• Protein ID: WP_014466399.1
• Coordinates: 15455..15727 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A0H3G4I9
• Locus tag: ZMOB_RS09145
• Protein ID: WP_014466400.1
• Coordinates: 15714..15977 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ZMOB_RS09120	10567..10851	+	285	WP_014466394.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ZMOB_RS09125	10954..11586	+	633	WP_014466395.1	ParA family protein	-
ZMOB_RS09130	11583..11858	+	276	WP_014466396.1	hypothetical protein	-
ZMOB_RS09140	13115..14713	+	1599	WP_014466397.1	AAA family ATPase	-
ZMOB_RS09980	15455..15727	-	273	WP_014466399.1	type II toxin-antitoxin system YafQ family toxin	Toxin
ZMOB_RS09145	15714..15977	-	264	WP_014466400.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ZMOB_RS09150	16153..16605	-	453	WP_014466401.1	hypothetical protein	-
ZMOB_RS09985	16853..17131	+	279	WP_014466402.1	ogr/Delta-like zinc finger family protein	-
ZMOB_RS09155	17121..17438	+	318	WP_014466403.1	hypothetical protein	-
ZMOB_RS09160	17563..17814	+	252	WP_014466405.1	DUF2312 domain-containing protein	-
ZMOB_RS09165	17921..19504	+	1584	WP_014466406.1	helix-turn-helix domain-containing protein	-
ZMOB_RS09170	19646..20209	-	564	WP_185738133.1	hypothetical protein	-
ZMOB_RS09175	20608..20889	-	282	WP_012817695.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..32479	32479

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-81)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10846.52 Da
• Isoelectric Point: 9.8184

>T26346 WP_014466399.1 NC_017180:c15727-15455 [Zymomonas mobilis subsp. mobilis ATCC 10988]
MRMIERTSQFKRDYKRERKSDPQLDKYFIPVVTHLASDVMLAPRLKDHSLTGNWNDHRECHIKPNLLLIYRKPDEYTLHL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T26346 NC_017180:c15727-15455 [Zymomonas mobilis subsp. mobilis ATCC 10988]
ATGCGGATGATTGAGCGAACATCTCAATTTAAACGCGATTACAAAAGAGAACGAAAGTCAGATCCGCAGTTAGATAAATA
TTTTATTCCTGTCGTTACCCATCTAGCCAGTGACGTTATGCTAGCTCCTCGTTTGAAGGATCATTCGTTGACGGGAAACT
GGAATGACCATCGGGAATGTCACATTAAGCCTAATTTGCTTTTAATTTACCGGAAGCCTGACGAATACACCCTTCATTTG
GTGCGGCTAGGATCTCATTCAGAGTTGTTTTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9511.13 Da
• Isoelectric Point: 8.6818

>AT26346 WP_014466400.1 NC_017180:c15977-15714 [Zymomonas mobilis subsp. mobilis ATCC 10988]
MAANQLVQARINGQIKQEAAVILESIGLTVSDAVRMMLTKVVQEKALPFDPLTPNKKTLAAMKDARAGKMKKFDSVQSLM
DDLHADD

Nucleotide

• Length: 264 bp

>AT26346 NC_017180:c15977-15714 [Zymomonas mobilis subsp. mobilis ATCC 10988]
ATGGCAGCTAATCAGCTCGTACAGGCTCGCATTAACGGACAGATAAAACAGGAGGCTGCTGTTATATTAGAAAGCATTGG
TCTGACGGTATCTGATGCTGTCCGCATGATGCTGACAAAAGTCGTTCAAGAAAAAGCTCTGCCTTTTGACCCTTTGACTC
CAAACAAAAAGACATTGGCTGCCATGAAAGACGCGCGTGCCGGTAAAATGAAAAAGTTCGACAGTGTTCAATCTCTGATG
GATGACCTTCATGCGGATGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3G4I9