Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1613263..1613906 Replicon chromosome
Accession NZ_CP110227
Organism Serratia rubidaea strain AO4-P6

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag OLD77_RS07470 Protein ID WP_269875370.1
Coordinates 1613263..1613679 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A126VIW5
Locus tag OLD77_RS07475 Protein ID WP_061322715.1
Coordinates 1613676..1613906 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLD77_RS07455 (OLD77_07455) 1608456..1610111 - 1656 WP_269875368.1 BCCT family transporter -
OLD77_RS07460 (OLD77_07460) 1610403..1611779 + 1377 WP_054307157.1 L-serine ammonia-lyase -
OLD77_RS07465 (OLD77_07465) 1612059..1613213 + 1155 WP_269875369.1 GlxA family transcriptional regulator -
OLD77_RS07470 (OLD77_07470) 1613263..1613679 - 417 WP_269875370.1 type II toxin-antitoxin system VapC family toxin Toxin
OLD77_RS07475 (OLD77_07475) 1613676..1613906 - 231 WP_061322715.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OLD77_RS07480 (OLD77_07480) 1614224..1615201 + 978 WP_269875371.1 dipeptidase -
OLD77_RS07485 (OLD77_07485) 1615233..1615763 + 531 WP_015673099.1 DUF5943 domain-containing protein -
OLD77_RS07490 (OLD77_07490) 1615820..1617883 + 2064 WP_015673098.1 dimethylglycine demethylation protein DgcA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14854.19 Da        Isoelectric Point: 7.8276

>T263459 WP_269875370.1 NZ_CP110227:c1613679-1613263 [Serratia rubidaea]
MSHTYMLDTCICSYIMREQPAAAIRRLEQAVMQRHRIVVSAITYAEMRFGAIGKKASPRHAQLVEAFCSRLDAILPWDRA
AVDETTALKAALAAAGTPIGPNDTAIAGHAIAAGAILVTNNHKEFARVPGLALEDWAA

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.83 Da        Isoelectric Point: 4.6182

>AT263459 WP_061322715.1 NZ_CP110227:c1613906-1613676 [Serratia rubidaea]
MRTVSVFKNGNNRAIRLPRDMDFAGVNELEIAREGDTIILRPVKPSWGSFLLEDKADADFMTEREDIINDEGRVKP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A126VIW5

References