Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 258621..259360 Replicon chromosome
Accession NZ_CP110227
Organism Serratia rubidaea strain AO4-P6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OLD77_RS01185 Protein ID WP_061321922.1
Coordinates 258621..259100 (-) Length 160 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L0MKT5
Locus tag OLD77_RS01190 Protein ID WP_015962211.1
Coordinates 259097..259360 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLD77_RS01170 (OLD77_01170) 255734..256207 - 474 WP_015962214.1 transcription elongation factor GreB -
OLD77_RS01175 (OLD77_01175) 256498..257217 + 720 WP_004709363.1 two-component system response regulator OmpR -
OLD77_RS01180 (OLD77_01180) 257214..258587 + 1374 WP_015962213.1 two-component system sensor histidine kinase EnvZ -
OLD77_RS01185 (OLD77_01185) 258621..259100 - 480 WP_061321922.1 type II toxin-antitoxin system VapC family toxin Toxin
OLD77_RS01190 (OLD77_01190) 259097..259360 - 264 WP_015962211.1 plasmid stability protein Antitoxin
OLD77_RS01195 (OLD77_01195) 259485..261104 - 1620 WP_061321923.1 phosphoenolpyruvate carboxykinase (ATP) -
OLD77_RS01200 (OLD77_01200) 261300..262181 - 882 WP_054305076.1 Hsp33 family molecular chaperone HslO -
OLD77_RS01205 (OLD77_01205) 262207..262614 - 408 WP_269874368.1 ribosome-associated heat shock protein Hsp15 -
OLD77_RS01210 (OLD77_01210) 262611..263291 - 681 WP_269874369.1 GMP/IMP nucleotidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17873.48 Da        Isoelectric Point: 4.9342

>T263457 WP_061321922.1 NZ_CP110227:c259100-258621 [Serratia rubidaea]
MIILDTNVISETLRPKPHYNVISWLNEKDNSELYLSAIVVAELFSGVACMPDGKRQQALRLRLAEAIQINFDEQILPFDA
LCAMQYAELMGRNQRQGTPMSAPDAQIAATCLQYGATLATRNTKDFLHCGIELIDPWQVPAGQRLHEDAAEYYVMSRKS

Download         Length: 480 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9834.22 Da        Isoelectric Point: 5.6211

>AT263457 WP_015962211.1 NZ_CP110227:c259360-259097 [Serratia rubidaea]
MATITVRNLDDEVKELLRISAAKNGHSMEEEARMILKQALMKKPARYGLGSWMHQHFAEFGGVELAIPPRDAVPPRRVTF
DDDDDQA

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A126VDX2

References