Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 821660..822308 Replicon chromosome
Accession NZ_CP110224
Organism Virgibacillus natechei strain DSM 25609

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OLD84_RS04560 Protein ID WP_209464504.1
Coordinates 821949..822308 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag OLD84_RS04555 Protein ID WP_209464503.1
Coordinates 821660..821944 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLD84_RS04525 (OLD84_04525) 817098..817457 + 360 WP_209464500.1 holo-ACP synthase -
OLD84_RS04530 (OLD84_04530) 817516..818154 + 639 WP_264917285.1 NAD(P)H-hydrate epimerase -
OLD84_RS04535 (OLD84_04535) 818211..818735 + 525 WP_264917286.1 ADP/ATP-dependent (S)-NAD(P)H-hydrate dehydratase -
OLD84_RS04540 (OLD84_04540) 818834..819118 + 285 WP_264917287.1 NAD(P)H-hydrate dehydratase -
OLD84_RS04545 (OLD84_04545) 819169..820188 + 1020 WP_209464501.1 outer membrane lipoprotein carrier protein LolA -
OLD84_RS04550 (OLD84_04550) 820383..821525 + 1143 WP_209464502.1 alanine racemase -
OLD84_RS04555 (OLD84_04555) 821660..821944 + 285 WP_209464503.1 antitoxin Antitoxin
OLD84_RS04560 (OLD84_04560) 821949..822308 + 360 WP_209464504.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OLD84_RS04565 (OLD84_04565) 823099..823968 + 870 WP_209464505.1 RsbT co-antagonist protein RsbRA -
OLD84_RS04570 (OLD84_04570) 823973..824329 + 357 WP_209464506.1 STAS domain-containing protein -
OLD84_RS04575 (OLD84_04575) 824332..824733 + 402 WP_209464507.1 anti-sigma regulatory factor -
OLD84_RS04580 (OLD84_04580) 824827..825837 + 1011 WP_209464508.1 PP2C family protein-serine/threonine phosphatase -
OLD84_RS04585 (OLD84_04585) 825931..826260 + 330 WP_209464509.1 STAS domain-containing protein -
OLD84_RS04590 (OLD84_04590) 826260..826733 + 474 WP_209464510.1 anti-sigma B factor RsbW -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13450.58 Da        Isoelectric Point: 6.4723

>T263452 WP_209464504.1 NZ_CP110224:821949-822308 [Virgibacillus natechei]
MIVQRGEVYFADLSPVVGSEQGGIRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKRYGFDRNSVILLEQI
RTLDKQRLTDKITKLDNEMMEKIDQALEISLGLKDMYDH

Download         Length: 360 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10646.88 Da        Isoelectric Point: 4.1739

>AT263452 WP_209464503.1 NZ_CP110224:821660-821944 [Virgibacillus natechei]
MSESSQEILVKLPTNLLNEVDGLMKYENSDLSDFISQATKNYLDQKKGEHVQQFRETMKKGYEEMAGINLTIASEAFQAE
EEAENTLERTVIGV

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References