Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4178891..4179672 Replicon chromosome
Accession NZ_CP110220
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain MFDS1018147

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag OF824_RS20415 Protein ID WP_000626100.1
Coordinates 4178891..4179382 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag OF824_RS20420 Protein ID WP_001110452.1
Coordinates 4179379..4179672 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF824_RS20380 (4174351) 4174351..4174698 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
OF824_RS20385 (4174674) 4174674..4176377 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
OF824_RS20390 (4176414) 4176414..4176989 + 576 WP_001188509.1 transcriptional regulator -
OF824_RS20400 (4177260) 4177260..4177334 - 75 Protein_3985 helix-turn-helix domain-containing protein -
OF824_RS20405 (4177714) 4177714..4177791 + 78 Protein_3986 porin family protein -
OF824_RS20410 (4177891) 4177891..4178643 + 753 WP_000842433.1 non-specific acid phosphatase -
OF824_RS20415 (4178891) 4178891..4179382 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
OF824_RS20420 (4179379) 4179379..4179672 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
OF824_RS20425 (4179989) 4179989..4180210 + 222 WP_001576552.1 hypothetical protein -
OF824_RS20430 (4180476) 4180476..4181351 + 876 WP_000921676.1 AraC family transcriptional regulator -
OF824_RS20435 (4181348) 4181348..4181635 + 288 WP_001541332.1 transcriptional regulator RtsB -
OF824_RS20440 (4181628) 4181628..4181936 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
OF824_RS20445 (4181935) 4181935..4182183 + 249 Protein_3994 Ig-like domain-containing protein -
OF824_RS20450 (4182295) 4182295..4182426 + 132 Protein_3995 hypothetical protein -
OF824_RS20455 (4182720) 4182720..4183625 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T263449 WP_000626100.1 NZ_CP110220:c4179382-4178891 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT263449 WP_001110452.1 NZ_CP110220:c4179672-4179379 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References