Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4071995..4072511 Replicon chromosome
Accession NZ_CP110220
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain MFDS1018147

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag OF824_RS19840 Protein ID WP_000220582.1
Coordinates 4071995..4072279 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag OF824_RS19845 Protein ID WP_000212724.1
Coordinates 4072269..4072511 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF824_RS19825 (4067206) 4067206..4068858 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
OF824_RS19830 (4069267) 4069267..4071405 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
OF824_RS19835 (4071527) 4071527..4071991 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OF824_RS19840 (4071995) 4071995..4072279 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OF824_RS19845 (4072269) 4072269..4072511 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OF824_RS19850 (4072589) 4072589..4074502 - 1914 WP_001212142.1 BglG family transcription antiterminator -
OF824_RS19855 (4074519) 4074519..4075259 - 741 WP_000779259.1 KDGP aldolase family protein -
OF824_RS19860 (4075256) 4075256..4076374 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
OF824_RS19865 (4076358) 4076358..4077491 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T263448 WP_000220582.1 NZ_CP110220:c4072279-4071995 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT263448 WP_000212724.1 NZ_CP110220:c4072511-4072269 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References