Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3980595..3981171 Replicon chromosome
Accession NZ_CP110220
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain MFDS1018147

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag OF824_RS19400 Protein ID WP_001131963.1
Coordinates 3980884..3981171 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag OF824_RS19395 Protein ID WP_000063142.1
Coordinates 3980595..3980897 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF824_RS19380 (3977105) 3977105..3979255 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
OF824_RS19385 (3979350) 3979350..3979553 + 204 WP_000460616.1 YbdD/YjiX family protein -
OF824_RS19390 (3979564) 3979564..3980520 + 957 WP_000187843.1 GTPase -
OF824_RS19395 (3980595) 3980595..3980897 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
OF824_RS19400 (3980884) 3980884..3981171 - 288 WP_001131963.1 BrnT family toxin Toxin
OF824_RS19405 (3981602) 3981602..3983443 + 1842 WP_000974637.1 nuclease-related domain-containing DEAD/DEAH box helicase -
OF824_RS19410 (3984056) 3984056..3984631 + 576 WP_000593784.1 restriction endonuclease subunit S -
OF824_RS19415 (3984636) 3984636..3985889 + 1254 WP_001206755.1 N-6 DNA methylase -
OF824_RS19420 (3985921) 3985921..3986055 - 135 WP_001055725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T263446 WP_001131963.1 NZ_CP110220:c3981171-3980884 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT263446 WP_000063142.1 NZ_CP110220:c3980897-3980595 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References