Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3405067..3405687 Replicon chromosome
Accession NZ_CP110220
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain MFDS1018147

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag OF824_RS16755 Protein ID WP_001280991.1
Coordinates 3405469..3405687 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag OF824_RS16750 Protein ID WP_000344807.1
Coordinates 3405067..3405441 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF824_RS16740 (3400206) 3400206..3401399 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OF824_RS16745 (3401422) 3401422..3404571 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
OF824_RS16750 (3405067) 3405067..3405441 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
OF824_RS16755 (3405469) 3405469..3405687 + 219 WP_001280991.1 HHA domain-containing protein Toxin
OF824_RS16760 (3405866) 3405866..3406417 + 552 WP_001278793.1 maltose O-acetyltransferase -
OF824_RS16765 (3406535) 3406535..3407005 + 471 WP_000136183.1 YlaC family protein -
OF824_RS16770 (3407061) 3407061..3407201 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
OF824_RS16775 (3407207) 3407207..3407467 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
OF824_RS16780 (3407692) 3407692..3409242 + 1551 WP_000213140.1 EAL domain-containing protein -
OF824_RS16790 (3409473) 3409473..3409862 + 390 WP_000961287.1 MGMT family protein -
OF824_RS16795 (3409895) 3409895..3410464 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T263443 WP_001280991.1 NZ_CP110220:3405469-3405687 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT263443 WP_000344807.1 NZ_CP110220:3405067-3405441 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References