Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4417067..4417848 Replicon chromosome
Accession NZ_CP110198
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 1104-75

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag OCK70_RS21575 Protein ID WP_000626099.1
Coordinates 4417067..4417558 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag OCK70_RS21580 Protein ID WP_001110452.1
Coordinates 4417555..4417848 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCK70_RS21535 (4412253) 4412253..4412495 - 243 WP_197603740.1 hypothetical protein -
OCK70_RS21540 (4412492) 4412492..4412848 - 357 WP_033567083.1 hypothetical protein -
OCK70_RS21545 (4412845) 4412845..4413717 - 873 WP_033567082.1 ParA family protein -
OCK70_RS21550 (4413908) 4413908..4413985 - 78 Protein_4215 helix-turn-helix domain-containing protein -
OCK70_RS21555 (4414076) 4414076..4414408 - 333 WP_001165471.1 MerR family transcriptional regulator -
OCK70_RS21560 (4414480) 4414480..4414857 + 378 WP_000916345.1 EthD family reductase -
OCK70_RS21565 (4415890) 4415890..4415964 + 75 Protein_4218 porin family protein -
OCK70_RS21570 (4416067) 4416067..4416819 + 753 WP_000842434.1 non-specific acid phosphatase -
OCK70_RS21575 (4417067) 4417067..4417558 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
OCK70_RS21580 (4417555) 4417555..4417848 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
OCK70_RS21585 (4418165) 4418165..4418386 + 222 WP_001576552.1 hypothetical protein -
OCK70_RS21590 (4418651) 4418651..4419526 + 876 WP_000921674.1 AraC family transcriptional regulator -
OCK70_RS21595 (4419523) 4419523..4419810 + 288 WP_001269916.1 transcriptional regulator RtsB -
OCK70_RS21600 (4419833) 4419833..4420048 + 216 WP_001595136.1 hypothetical protein -
OCK70_RS21605 (4420056) 4420056..4420325 + 270 WP_010989096.1 hypothetical protein -
OCK70_RS21610 (4420619) 4420619..4421524 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T263405 WP_000626099.1 NZ_CP110198:c4417558-4417067 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT263405 WP_001110452.1 NZ_CP110198:c4417848-4417555 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References