Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4206989..4207505 Replicon chromosome
Accession NZ_CP110198
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 1104-75

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag OCK70_RS20470 Protein ID WP_000220578.1
Coordinates 4206989..4207273 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag OCK70_RS20475 Protein ID WP_000212724.1
Coordinates 4207263..4207505 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCK70_RS20455 (4202201) 4202201..4203853 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
OCK70_RS20460 (4204262) 4204262..4206400 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
OCK70_RS20465 (4206521) 4206521..4206985 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OCK70_RS20470 (4206989) 4206989..4207273 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCK70_RS20475 (4207263) 4207263..4207505 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OCK70_RS20480 (4207583) 4207583..4209496 - 1914 WP_001212137.1 BglG family transcription antiterminator -
OCK70_RS20485 (4209513) 4209513..4210253 - 741 WP_000779263.1 KDGP aldolase family protein -
OCK70_RS20490 (4210250) 4210250..4211368 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
OCK70_RS20495 (4211352) 4211352..4212485 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T263404 WP_000220578.1 NZ_CP110198:c4207273-4206989 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT263404 WP_000212724.1 NZ_CP110198:c4207505-4207263 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References