Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3493814..3494434 Replicon chromosome
Accession NZ_CP110198
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 1104-75

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag OCK70_RS17195 Protein ID WP_001280991.1
Coordinates 3494216..3494434 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag OCK70_RS17190 Protein ID WP_000344807.1
Coordinates 3493814..3494188 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCK70_RS17180 (3488953) 3488953..3490146 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OCK70_RS17185 (3490169) 3490169..3493318 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
OCK70_RS17190 (3493814) 3493814..3494188 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
OCK70_RS17195 (3494216) 3494216..3494434 + 219 WP_001280991.1 HHA domain-containing protein Toxin
OCK70_RS17200 (3494613) 3494613..3495164 + 552 WP_001278792.1 maltose O-acetyltransferase -
OCK70_RS17205 (3495281) 3495281..3495751 + 471 WP_000136181.1 YlaC family protein -
OCK70_RS17210 (3495807) 3495807..3495947 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
OCK70_RS17215 (3495953) 3495953..3496213 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
OCK70_RS17220 (3496438) 3496438..3497988 + 1551 WP_000213139.1 EAL domain-containing protein -
OCK70_RS17230 (3498219) 3498219..3498608 + 390 WP_000961285.1 MGMT family protein -
OCK70_RS17235 (3498641) 3498641..3499210 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T263400 WP_001280991.1 NZ_CP110198:3494216-3494434 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT263400 WP_000344807.1 NZ_CP110198:3493814-3494188 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References