Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 41236..41761 Replicon plasmid p2FK563
Accession NZ_CP110195
Organism Klebsiella pneumoniae strain FK563

Toxin (Protein)


Gene name ccdB Uniprot ID D4HQE7
Locus tag OEW01_RS27180 Protein ID WP_013023785.1
Coordinates 41456..41761 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag OEW01_RS27175 Protein ID WP_001568025.1
Coordinates 41236..41454 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEW01_RS27155 (OEW01_27155) 36392..37171 + 780 WP_013023780.1 hypothetical protein -
OEW01_RS27160 (OEW01_27160) 37447..38970 + 1524 WP_017899887.1 hypothetical protein -
OEW01_RS27165 (OEW01_27165) 39004..40131 + 1128 WP_013023782.1 DUF4238 domain-containing protein -
OEW01_RS27170 (OEW01_27170) 40128..40418 + 291 WP_013023783.1 hypothetical protein -
OEW01_RS27175 (OEW01_27175) 41236..41454 + 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
OEW01_RS27180 (OEW01_27180) 41456..41761 + 306 WP_013023785.1 type II toxin-antitoxin system toxin CcdB Toxin
OEW01_RS27185 (OEW01_27185) 41930..42325 + 396 WP_017899885.1 hypothetical protein -
OEW01_RS27190 (OEW01_27190) 42352..42666 + 315 WP_053389906.1 hypothetical protein -
OEW01_RS27195 (OEW01_27195) 42677..43693 + 1017 WP_017899884.1 hypothetical protein -
OEW01_RS27200 (OEW01_27200) 43891..44685 + 795 WP_004197635.1 site-specific integrase -
OEW01_RS27205 (OEW01_27205) 45117..45419 - 303 WP_004197636.1 hypothetical protein -
OEW01_RS27210 (OEW01_27210) 45416..46042 - 627 WP_004197649.1 ParA family plasmid-partitioning AAA ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-15 / blaTEM-1B - 1..94216 94216


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11615.30 Da        Isoelectric Point: 6.4672

>T263387 WP_013023785.1 NZ_CP110195:41456-41761 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT263387 WP_001568025.1 NZ_CP110195:41236-41454 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4ZZW6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References