Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5269638..5270263 Replicon chromosome
Accession NZ_CP110193
Organism Klebsiella pneumoniae strain FK563

Toxin (Protein)


Gene name vapC Uniprot ID A0A483GDF6
Locus tag OEW01_RS25665 Protein ID WP_004187928.1
Coordinates 5269638..5270021 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OEW01_RS25670 Protein ID WP_004150355.1
Coordinates 5270021..5270263 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEW01_RS25650 (5267004) 5267004..5267906 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OEW01_RS25655 (5267903) 5267903..5268538 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OEW01_RS25660 (5268535) 5268535..5269464 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OEW01_RS25665 (5269638) 5269638..5270021 - 384 WP_004187928.1 type II toxin-antitoxin system VapC family toxin Toxin
OEW01_RS25670 (5270021) 5270021..5270263 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OEW01_RS25675 (5270457) 5270457..5271374 + 918 WP_105910615.1 alpha/beta hydrolase -
OEW01_RS25680 (5271388) 5271388..5272329 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OEW01_RS25685 (5272374) 5272374..5272811 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OEW01_RS25690 (5272808) 5272808..5273668 - 861 WP_004146232.1 virulence factor BrkB family protein -
OEW01_RS25695 (5273662) 5273662..5274261 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14407.64 Da        Isoelectric Point: 7.3178

>T263378 WP_004187928.1 NZ_CP110193:c5270021-5269638 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT263378 WP_004150355.1 NZ_CP110193:c5270263-5270021 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GDF6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References