Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4783989..4784505 Replicon chromosome
Accession NZ_CP110193
Organism Klebsiella pneumoniae strain FK563

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag OEW01_RS23355 Protein ID WP_004192395.1
Coordinates 4783989..4784273 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag OEW01_RS23360 Protein ID WP_004192397.1
Coordinates 4784263..4784505 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEW01_RS23330 (4779406) 4779406..4779669 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
OEW01_RS23335 (4779799) 4779799..4779972 + 174 WP_002886906.1 hypothetical protein -
OEW01_RS23340 (4779975) 4779975..4780718 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OEW01_RS23345 (4781075) 4781075..4783213 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OEW01_RS23350 (4783521) 4783521..4783985 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OEW01_RS23355 (4783989) 4783989..4784273 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OEW01_RS23360 (4784263) 4784263..4784505 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OEW01_RS23365 (4784583) 4784583..4786493 - 1911 WP_004152270.1 PRD domain-containing protein -
OEW01_RS23370 (4786516) 4786516..4787670 - 1155 WP_004178372.1 lactonase family protein -
OEW01_RS23375 (4787737) 4787737..4788477 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T263376 WP_004192395.1 NZ_CP110193:c4784273-4783989 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT263376 WP_004192397.1 NZ_CP110193:c4784505-4784263 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References