Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4675509..4676319 Replicon chromosome
Accession NZ_CP110193
Organism Klebsiella pneumoniae strain FK563

Toxin (Protein)


Gene name KacT Uniprot ID A0A483G813
Locus tag OEW01_RS22830 Protein ID WP_023279404.1
Coordinates 4675509..4676042 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag OEW01_RS22835 Protein ID WP_002887278.1
Coordinates 4676053..4676319 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEW01_RS22825 (4674340) 4674340..4675461 + 1122 WP_002887282.1 cupin domain-containing protein -
OEW01_RS22830 (4675509) 4675509..4676042 - 534 WP_023279404.1 type II toxin-antitoxin system toxin KacT Toxin
OEW01_RS22835 (4676053) 4676053..4676319 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
OEW01_RS22840 (4676422) 4676422..4677855 - 1434 WP_004192214.1 Cu(+)/Ag(+) sensor histidine kinase -
OEW01_RS22845 (4677845) 4677845..4678528 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
OEW01_RS22850 (4678700) 4678700..4680085 + 1386 WP_004192218.1 efflux transporter outer membrane subunit -
OEW01_RS22855 (4680103) 4680103..4680447 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19809.71 Da        Isoelectric Point: 6.2369

>T263375 WP_023279404.1 NZ_CP110193:c4676042-4675509 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDKNSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT263375 WP_002887278.1 NZ_CP110193:c4676319-4676053 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483G813

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References