Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2662620..2664208 Replicon chromosome
Accession NZ_CP110193
Organism Klebsiella pneumoniae strain FK563

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag OEW01_RS13005 Protein ID WP_004190166.1
Coordinates 2662620..2663942 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag OEW01_RS13010 Protein ID WP_002904790.1
Coordinates 2663942..2664208 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEW01_RS12990 (2657676) 2657676..2660177 + 2502 WP_102010286.1 fimbria/pilus outer membrane usher protein -
OEW01_RS12995 (2660165) 2660165..2661169 + 1005 WP_004190163.1 fimbrial protein -
OEW01_RS13000 (2661311) 2661311..2662603 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OEW01_RS13005 (2662620) 2662620..2663942 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
OEW01_RS13010 (2663942) 2663942..2664208 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OEW01_RS13015 (2664473) 2664473..2664799 - 327 WP_004143476.1 hydroxyisourate hydrolase -
OEW01_RS13020 (2664796) 2664796..2665296 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OEW01_RS13025 (2665274) 2665274..2666653 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
OEW01_RS13030 (2666999) 2666999..2668153 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OEW01_RS13035 (2668134) 2668134..2669057 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T263372 WP_004190166.1 NZ_CP110193:c2663942-2662620 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT263372 WP_002904790.1 NZ_CP110193:c2664208-2663942 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References