Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 819273..819930 Replicon chromosome
Accession NZ_CP110193
Organism Klebsiella pneumoniae strain FK563

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OEW01_RS04075 Protein ID WP_002916310.1
Coordinates 819520..819930 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OEW01_RS04070 Protein ID WP_002916312.1
Coordinates 819273..819539 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEW01_RS04045 (814429) 814429..815862 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
OEW01_RS04050 (815981) 815981..816709 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OEW01_RS04055 (816759) 816759..817070 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OEW01_RS04060 (817234) 817234..817893 + 660 WP_002916317.1 hemolysin III family protein -
OEW01_RS04065 (818044) 818044..819027 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OEW01_RS04070 (819273) 819273..819539 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OEW01_RS04075 (819520) 819520..819930 + 411 WP_002916310.1 protein YgfX Toxin
OEW01_RS04080 (819937) 819937..820458 - 522 WP_002916308.1 flavodoxin FldB -
OEW01_RS04085 (820559) 820559..821455 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OEW01_RS04090 (821478) 821478..822191 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OEW01_RS04095 (822197) 822197..823930 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T263367 WP_002916310.1 NZ_CP110193:819520-819930 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT263367 WP_002916312.1 NZ_CP110193:819273-819539 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References