263363

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 117050..117743 Replicon plasmid unnamed1
Accession NZ_CP110191
Organism Pseudomonas aeruginosa strain HS204

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag OMP51_RS32990 Protein ID WP_003151133.1
Coordinates 117366..117743 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag OMP51_RS32985 Protein ID WP_001172026.1
Coordinates 117050..117385 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMP51_RS32950 (OMP51_32935) 112222..113520 + 1299 WP_258154055.1 hypothetical protein -
OMP51_RS32955 (OMP51_32940) 113583..113837 - 255 WP_010792929.1 hypothetical protein -
OMP51_RS32960 (OMP51_32945) 114214..114573 + 360 WP_010792928.1 DUF805 domain-containing protein -
OMP51_RS32965 (OMP51_32950) 115408..115896 + 489 WP_038405174.1 hypothetical protein -
OMP51_RS32970 (OMP51_32955) 115993..116334 - 342 WP_025999701.1 hypothetical protein -
OMP51_RS32975 (OMP51_32960) 116350..116676 - 327 WP_000091614.1 hypothetical protein -
OMP51_RS32980 (OMP51_32965) 116700..117035 - 336 WP_000741275.1 hypothetical protein -
OMP51_RS32985 (OMP51_32970) 117050..117385 - 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
OMP51_RS32990 (OMP51_32975) 117366..117743 - 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OMP51_RS32995 (OMP51_32980) 117935..118537 + 603 WP_010465829.1 recombinase family protein -
OMP51_RS33000 (OMP51_32985) 118521..121550 + 3030 WP_010799689.1 Tn3 family transposase -
OMP51_RS33005 (OMP51_32990) 121645..122418 + 774 WP_258153958.1 3'-5' exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / blaPER-1 / qnrVC6 / qacE - 1..416612 416612


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T263363 WP_003151133.1 NZ_CP110191:c117743-117366 [Pseudomonas aeruginosa]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT263363 WP_001172026.1 NZ_CP110191:c117385-117050 [Pseudomonas aeruginosa]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References