Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 22800..23716 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP110191 | ||
| Organism | Pseudomonas aeruginosa strain HS204 | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | A0A212BIN6 |
| Locus tag | OMP51_RS32495 | Protein ID | WP_021018402.1 |
| Coordinates | 22800..23324 (-) | Length | 175 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | A0A2I0C738 |
| Locus tag | OMP51_RS32500 | Protein ID | WP_010792483.1 |
| Coordinates | 23321..23716 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OMP51_RS32475 (OMP51_32460) | 18116..19261 | + | 1146 | WP_021018404.1 | glycerate kinase | - |
| OMP51_RS32480 (OMP51_32465) | 19683..19874 | - | 192 | WP_010792486.1 | hypothetical protein | - |
| OMP51_RS32485 (OMP51_32470) | 20252..21307 | + | 1056 | WP_021018403.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| OMP51_RS32490 (OMP51_32475) | 21504..22754 | + | 1251 | WP_010792484.1 | TerD family protein | - |
| OMP51_RS32495 (OMP51_32480) | 22800..23324 | - | 525 | WP_021018402.1 | RES family NAD+ phosphorylase | Toxin |
| OMP51_RS32500 (OMP51_32485) | 23321..23716 | - | 396 | WP_010792483.1 | hypothetical protein | Antitoxin |
| OMP51_RS32505 (OMP51_32490) | 23926..25860 | - | 1935 | WP_021018401.1 | hypothetical protein | - |
| OMP51_RS32510 (OMP51_32495) | 27169..27693 | + | 525 | WP_010792479.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sul1 / blaPER-1 / qnrVC6 / qacE | - | 1..416612 | 416612 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 175 a.a. Molecular weight: 19011.47 Da Isoelectric Point: 4.4540
>T263362 WP_021018402.1 NZ_CP110191:c23324-22800 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
Download Length: 525 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14810.93 Da Isoelectric Point: 7.2048
>AT263362 WP_010792483.1 NZ_CP110191:c23716-23321 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A212BIN6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I0C738 |