Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5545382..5545968 Replicon chromosome
Accession NZ_CP110190
Organism Pseudomonas aeruginosa strain HS204

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag OMP51_RS26250 Protein ID WP_003120987.1
Coordinates 5545669..5545968 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag OMP51_RS26245 Protein ID WP_003448662.1
Coordinates 5545382..5545672 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMP51_RS26225 (OMP51_26210) 5541204..5543180 + 1977 WP_010792226.1 DEAD/DEAH box helicase -
OMP51_RS26230 (OMP51_26215) 5543190..5543324 + 135 WP_033179080.1 hypothetical protein -
OMP51_RS26235 (OMP51_26220) 5543321..5543614 + 294 WP_049881459.1 hypothetical protein -
OMP51_RS26240 (OMP51_26225) 5543696..5544967 + 1272 WP_023082545.1 IS4-like element ISPa1635 family transposase -
OMP51_RS26245 (OMP51_26230) 5545382..5545672 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
OMP51_RS26250 (OMP51_26235) 5545669..5545968 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OMP51_RS26255 (OMP51_26240) 5546170..5547291 + 1122 WP_003448658.1 TcpQ domain-containing protein -
OMP51_RS26260 (OMP51_26245) 5547291..5549000 + 1710 WP_010792227.1 PilN family type IVB pilus formation outer membrane protein -
OMP51_RS26265 (OMP51_26250) 5549004..5550329 + 1326 WP_003120992.1 type 4b pilus protein PilO2 -
OMP51_RS26270 (OMP51_26255) 5550319..5550852 + 534 WP_003120993.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5513400..5602431 89031
- flank IS/Tn - - 5543696..5544967 1271


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T263360 WP_003120987.1 NZ_CP110190:c5545968-5545669 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT263360 WP_003448662.1 NZ_CP110190:c5545672-5545382 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References