Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5453851..5454437 Replicon chromosome
Accession NZ_CP110190
Organism Pseudomonas aeruginosa strain HS204

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag OMP51_RS25745 Protein ID WP_003120987.1
Coordinates 5454138..5454437 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag OMP51_RS25740 Protein ID WP_003448662.1
Coordinates 5453851..5454141 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMP51_RS25720 (OMP51_25705) 5449433..5451322 + 1890 WP_196994395.1 hypothetical protein -
OMP51_RS25725 (OMP51_25710) 5451319..5453295 + 1977 WP_016851611.1 DEAD/DEAH box helicase -
OMP51_RS25730 (OMP51_25715) 5453305..5453439 + 135 WP_255253641.1 hypothetical protein -
OMP51_RS25735 (OMP51_25720) 5453436..5453780 + 345 WP_016851612.1 hypothetical protein -
OMP51_RS25740 (OMP51_25725) 5453851..5454141 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
OMP51_RS25745 (OMP51_25730) 5454138..5454437 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OMP51_RS25750 (OMP51_25735) 5454639..5455763 + 1125 WP_012076859.1 TcpQ domain-containing protein -
OMP51_RS25755 (OMP51_25740) 5455763..5457472 + 1710 WP_003099757.1 PilN family type IVB pilus formation outer membrane protein -
OMP51_RS25760 (OMP51_25745) 5457476..5458801 + 1326 WP_003099758.1 type 4b pilus protein PilO2 -
OMP51_RS25765 (OMP51_25750) 5458791..5459324 + 534 WP_003099760.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T263359 WP_003120987.1 NZ_CP110190:c5454437-5454138 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT263359 WP_003448662.1 NZ_CP110190:c5454141-5453851 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References