263358

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5039811..5040419 Replicon chromosome
Accession NZ_CP110190
Organism Pseudomonas aeruginosa strain HS204

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag OMP51_RS23840 Protein ID WP_019486378.1
Coordinates 5039811..5040158 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag OMP51_RS23845 Protein ID WP_003114155.1
Coordinates 5040168..5040419 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMP51_RS23815 (OMP51_23800) 5036038..5036361 + 324 WP_032958199.1 helix-turn-helix domain-containing protein -
OMP51_RS23820 (OMP51_23805) 5036366..5036863 + 498 WP_041104366.1 arsenate reductase ArsC -
OMP51_RS23825 (OMP51_23810) 5036871..5037956 + 1086 WP_280156736.1 ACR3 family arsenite efflux transporter -
OMP51_RS23830 (OMP51_23815) 5037970..5038392 + 423 WP_280156737.1 arsenate reductase (glutaredoxin) -
OMP51_RS23835 (OMP51_23820) 5038385..5039107 + 723 WP_032958192.1 arsenical resistance protein ArsH -
OMP51_RS23840 (OMP51_23825) 5039811..5040158 - 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OMP51_RS23845 (OMP51_23830) 5040168..5040419 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OMP51_RS23850 (OMP51_23835) 5040633..5041616 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
OMP51_RS23855 (OMP51_23840) 5041616..5042908 - 1293 WP_003115206.1 hypothetical protein -
OMP51_RS23860 (OMP51_23845) 5043138..5044412 - 1275 WP_179063290.1 zonular occludens toxin family protein -
OMP51_RS23865 (OMP51_23850) 5044416..5044772 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4890871..5051711 160840


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T263358 WP_019486378.1 NZ_CP110190:c5040158-5039811 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT263358 WP_003114155.1 NZ_CP110190:c5040419-5040168 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References