Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2845769..2846990 Replicon chromosome
Accession NZ_CP110190
Organism Pseudomonas aeruginosa strain HS204

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag OMP51_RS13675 Protein ID WP_003102740.1
Coordinates 2845769..2846347 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OMP51_RS13680 Protein ID WP_003088112.1
Coordinates 2846436..2846990 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMP51_RS13660 (OMP51_13655) 2841045..2842322 + 1278 WP_003102743.1 TolC family protein -
OMP51_RS13665 (OMP51_13660) 2842312..2844483 + 2172 WP_179063259.1 type I secretion system permease/ATPase -
OMP51_RS13670 (OMP51_13665) 2844473..2845660 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
OMP51_RS13675 (OMP51_13670) 2845769..2846347 - 579 WP_003102740.1 HD domain-containing protein Toxin
OMP51_RS13680 (OMP51_13675) 2846436..2846990 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
OMP51_RS13685 (OMP51_13680) 2847148..2849343 - 2196 WP_014603034.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
OMP51_RS13690 (OMP51_13685) 2849348..2849809 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
OMP51_RS13695 (OMP51_13690) 2850140..2850463 + 324 WP_003102734.1 multidrug efflux SMR transporter -
OMP51_RS13700 (OMP51_13695) 2850476..2850874 + 399 WP_003102731.1 NADH-quinone oxidoreductase subunit A -
OMP51_RS13705 (OMP51_13700) 2850871..2851422 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T263356 WP_003102740.1 NZ_CP110190:c2846347-2845769 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT263356 WP_003088112.1 NZ_CP110190:c2846990-2846436 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References