Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 149449..149954 Replicon chromosome
Accession NZ_CP110190
Organism Pseudomonas aeruginosa strain HS204

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag OMP51_RS00680 Protein ID WP_003083773.1
Coordinates 149449..149730 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag OMP51_RS00685 Protein ID WP_003083775.1
Coordinates 149727..149954 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMP51_RS00655 (OMP51_00655) 144700..146049 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
OMP51_RS00660 (OMP51_00660) 146098..146784 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
OMP51_RS00665 (OMP51_00665) 146885..147619 + 735 WP_004346926.1 GntR family transcriptional regulator -
OMP51_RS00670 (OMP51_00670) 147799..148209 + 411 WP_003101225.1 aegerolysin family protein -
OMP51_RS00675 (OMP51_00675) 148241..149149 - 909 WP_003083769.1 LysR family transcriptional regulator -
OMP51_RS00680 (OMP51_00680) 149449..149730 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
OMP51_RS00685 (OMP51_00685) 149727..149954 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
OMP51_RS00690 (OMP51_00690) 150130..150750 - 621 WP_003101226.1 hypothetical protein -
OMP51_RS00695 (OMP51_00695) 150851..151351 + 501 WP_003112629.1 LEA type 2 family protein -
OMP51_RS00700 (OMP51_00700) 151424..151765 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
OMP51_RS00705 (OMP51_00705) 151847..153274 - 1428 WP_003083784.1 GABA permease -
OMP51_RS00710 (OMP51_00710) 153443..154936 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T263354 WP_003083773.1 NZ_CP110190:c149730-149449 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT263354 WP_003083775.1 NZ_CP110190:c149954-149727 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References