Detailed information of TA system TA263347

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 1014273..1015057
• Replicon: chromosome
• Accession: NZ_CP110189
• Organism: Vibrio cholerae strain E1

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: OFY13_RS17940
• Protein ID: WP_001114075.1
• Coordinates: 1014788..1015057 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: Q9KM84
• Locus tag: OFY13_RS17935
• Protein ID: WP_000921691.1
• Coordinates: 1014273..1014794 (-)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OFY13_RS17900 (OFY13_17900)	1009466..1010644	-	1179	Protein_860	IS3-like element ISVch4 family transposase	-
OFY13_RS17905 (OFY13_17905)	1011199..1011612	-	414	WP_000049420.1	VOC family protein	-
OFY13_RS17910 (OFY13_17910)	1011796..1012311	-	516	WP_000343779.1	GNAT family protein	-
OFY13_RS17915 (OFY13_17915)	1012505..1012789	+	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
OFY13_RS17920 (OFY13_17920)	1012786..1013064	+	279	WP_000578471.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
OFY13_RS17925 (OFY13_17925)	1013203..1013598	-	396	WP_001000868.1	hypothetical protein	-
OFY13_RS17930 (OFY13_17930)	1013849..1013974	-	126	WP_001905700.1	DUF645 family protein	-
OFY13_RS17935 (OFY13_17935)	1014273..1014794	-	522	WP_000921691.1	DUF2442 domain-containing protein	Antitoxin
OFY13_RS17940 (OFY13_17940)	1014788..1015057	-	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
OFY13_RS17945 (OFY13_17945)	1015564..1015635	-	72	Protein_869	iron transporter	-
OFY13_RS17950 (OFY13_17950)	1015692..1016228	-	537	WP_000469484.1	GNAT family protein	-
OFY13_RS17955 (OFY13_17955)	1016516..1016734	-	219	Protein_871	DUF3709 domain-containing protein	-
OFY13_RS17960 (OFY13_17960)	1016777..1016839	-	63	WP_229636691.1	hypothetical protein	-
OFY13_RS17965 (OFY13_17965)	1017022..1017621	-	600	WP_001891245.1	glutathione S-transferase N-terminal domain-containing protein	-
OFY13_RS17970 (OFY13_17970)	1017771..1018118	-	348	Protein_874	DUF3800 domain-containing protein	-
OFY13_RS17975 (OFY13_17975)	1018193..1019382	+	1190	WP_088124793.1	IS3 family transposase	-
OFY13_RS17980 (OFY13_17980)	1019391..1019918	-	528	Protein_876	DUF3800 domain-containing protein	-
OFY13_RS17985 (OFY13_17985)	1019968..1020036	-	69	Protein_877	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1003220..1033507	30287
	-	inside	Integron	-	hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA	44..1062811	1062767

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T263347 WP_001114075.1 NZ_CP110189:c1015057-1014788 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19409.01 Da
• Isoelectric Point: 6.7342

>AT263347 WP_000921691.1 NZ_CP110189:c1014794-1014273 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

Structures

Toxin

• AlphaFold DB: A0A086SLD6

Antitoxin

• AlphaFold DB: Q9KM84