Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2187676..2189501 Replicon chromosome
Accession NZ_CP110188
Organism Vibrio cholerae strain E1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OFY13_RS09900 Protein ID WP_142993673.1
Coordinates 2187676..2189037 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OFY13_RS09905 Protein ID WP_046127336.1
Coordinates 2189034..2189501 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OFY13_RS09870 (OFY13_09870) 2183207..2184871 + 1665 WP_085604439.1 DNA repair protein RecN -
OFY13_RS09875 (OFY13_09875) 2185030..2185389 + 360 WP_001160907.1 outer membrane protein assembly factor BamE -
OFY13_RS09880 (OFY13_09880) 2185468..2185773 - 306 WP_001929603.1 RnfH family protein -
OFY13_RS09885 (OFY13_09885) 2185776..2186210 - 435 WP_000815880.1 type II toxin-antitoxin system RatA family toxin -
OFY13_RS09890 (OFY13_09890) 2186394..2186879 + 486 WP_000162689.1 SsrA-binding protein SmpB -
OFY13_RS09900 (OFY13_09900) 2187676..2189037 + 1362 WP_142993673.1 type II toxin-antitoxin system HipA family toxin Toxin
OFY13_RS09905 (OFY13_09905) 2189034..2189501 + 468 WP_046127336.1 helix-turn-helix transcriptional regulator Antitoxin
OFY13_RS09910 (OFY13_09910) 2190083..2193223 - 3141 WP_264879858.1 DEAD/DEAH box helicase -
OFY13_RS09915 (OFY13_09915) 2193650..2194333 + 684 WP_000841479.1 VC0807 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51331.23 Da        Isoelectric Point: 4.8586

>T263344 WP_142993673.1 NZ_CP110188:2187676-2189037 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17077.54 Da        Isoelectric Point: 10.7084

>AT263344 WP_046127336.1 NZ_CP110188:2189034-2189501 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKNATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDTLKSLLMDGEDG

Download         Length: 468 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References