Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5217230..5217855 Replicon chromosome
Accession NZ_CP110170
Organism Klebsiella pneumoniae strain YZ22PK089

Toxin (Protein)


Gene name vapC Uniprot ID A0A378FVD4
Locus tag OK017_RS25595 Protein ID WP_019705794.1
Coordinates 5217230..5217613 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OK017_RS25600 Protein ID WP_004150355.1
Coordinates 5217613..5217855 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK017_RS25580 (5214596) 5214596..5215498 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OK017_RS25585 (5215495) 5215495..5216130 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OK017_RS25590 (5216127) 5216127..5217056 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OK017_RS25595 (5217230) 5217230..5217613 - 384 WP_019705794.1 type II toxin-antitoxin system VapC family toxin Toxin
OK017_RS25600 (5217613) 5217613..5217855 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OK017_RS25605 (5218060) 5218060..5218977 + 918 WP_004146235.1 alpha/beta hydrolase -
OK017_RS25610 (5218992) 5218992..5219933 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OK017_RS25615 (5219978) 5219978..5220415 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OK017_RS25620 (5220412) 5220412..5221272 - 861 WP_004146232.1 virulence factor BrkB family protein -
OK017_RS25625 (5221266) 5221266..5221865 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14358.57 Da        Isoelectric Point: 6.8806

>T263342 WP_019705794.1 NZ_CP110170:c5217613-5217230 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGHREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT263342 WP_004150355.1 NZ_CP110170:c5217855-5217613 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378FVD4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References