Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4875091..4876772 Replicon chromosome
Accession NZ_CP110170
Organism Klebsiella pneumoniae strain YZ22PK089

Toxin (Protein)


Gene name mosT Uniprot ID A0A483YLF8
Locus tag OK017_RS24040 Protein ID WP_019724882.1
Coordinates 4875091..4876008 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag OK017_RS24045 Protein ID WP_004177809.1
Coordinates 4876014..4876772 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK017_RS24020 (4870397) 4870397..4871917 + 1521 WP_004210021.1 sugar ABC transporter ATP-binding protein -
OK017_RS24025 (4871914) 4871914..4872912 + 999 WP_002885172.1 ribose ABC transporter permease -
OK017_RS24030 (4872943) 4872943..4873884 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OK017_RS24035 (4873959) 4873959..4874966 + 1008 WP_064152101.1 carbohydrate kinase family protein -
OK017_RS24040 (4875091) 4875091..4876008 - 918 WP_019724882.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OK017_RS24045 (4876014) 4876014..4876772 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OK017_RS24050 (4876858) 4876858..4877586 - 729 WP_002885152.1 response regulator transcription factor -
OK017_RS24055 (4877859) 4877859..4880006 + 2148 WP_077625403.1 formate dehydrogenase subunit alpha -
OK017_RS24060 (4880236) 4880236..4880922 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34653.14 Da        Isoelectric Point: 5.4707

>T263341 WP_019724882.1 NZ_CP110170:c4876008-4875091 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT263341 WP_004177809.1 NZ_CP110170:c4876772-4876014 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YLF8

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References