Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 4719614..4720130 | Replicon | chromosome |
Accession | NZ_CP110170 | ||
Organism | Klebsiella pneumoniae strain YZ22PK089 |
Toxin (Protein)
Gene name | relE | Uniprot ID | R4YAY3 |
Locus tag | OK017_RS23235 | Protein ID | WP_004178374.1 |
Coordinates | 4719614..4719898 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | R4Y888 |
Locus tag | OK017_RS23240 | Protein ID | WP_002886901.1 |
Coordinates | 4719888..4720130 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OK017_RS23210 (4715009) | 4715009..4715272 | - | 264 | WP_014908078.1 | PTS sugar transporter subunit IIB | - |
OK017_RS23215 (4715402) | 4715402..4715575 | + | 174 | WP_032412860.1 | hypothetical protein | - |
OK017_RS23220 (4715578) | 4715578..4716321 | + | 744 | WP_002886905.1 | MurR/RpiR family transcriptional regulator | - |
OK017_RS23225 (4716678) | 4716678..4718816 | + | 2139 | WP_004186701.1 | anaerobic ribonucleoside-triphosphate reductase | - |
OK017_RS23230 (4719146) | 4719146..4719610 | + | 465 | WP_004178375.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
OK017_RS23235 (4719614) | 4719614..4719898 | - | 285 | WP_004178374.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
OK017_RS23240 (4719888) | 4719888..4720130 | - | 243 | WP_002886901.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
OK017_RS23245 (4720208) | 4720208..4722118 | - | 1911 | WP_004152270.1 | PRD domain-containing protein | - |
OK017_RS23250 (4722141) | 4722141..4723295 | - | 1155 | WP_002886900.1 | lactonase family protein | - |
OK017_RS23255 (4723362) | 4723362..4724102 | - | 741 | WP_002886899.1 | KDGP aldolase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11155.97 Da Isoelectric Point: 10.3787
>T263340 WP_004178374.1 NZ_CP110170:c4719898-4719614 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
Download Length: 285 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A6THG1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GLP0 |