Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4719614..4720130 Replicon chromosome
Accession NZ_CP110170
Organism Klebsiella pneumoniae strain YZ22PK089

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OK017_RS23235 Protein ID WP_004178374.1
Coordinates 4719614..4719898 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OK017_RS23240 Protein ID WP_002886901.1
Coordinates 4719888..4720130 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK017_RS23210 (4715009) 4715009..4715272 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
OK017_RS23215 (4715402) 4715402..4715575 + 174 WP_032412860.1 hypothetical protein -
OK017_RS23220 (4715578) 4715578..4716321 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OK017_RS23225 (4716678) 4716678..4718816 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OK017_RS23230 (4719146) 4719146..4719610 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OK017_RS23235 (4719614) 4719614..4719898 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OK017_RS23240 (4719888) 4719888..4720130 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OK017_RS23245 (4720208) 4720208..4722118 - 1911 WP_004152270.1 PRD domain-containing protein -
OK017_RS23250 (4722141) 4722141..4723295 - 1155 WP_002886900.1 lactonase family protein -
OK017_RS23255 (4723362) 4723362..4724102 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T263340 WP_004178374.1 NZ_CP110170:c4719898-4719614 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp


Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT263340 WP_002886901.1 NZ_CP110170:c4720130-4719888 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A6THG1


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References