Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 797892..798549 Replicon chromosome
Accession NZ_CP110170
Organism Klebsiella pneumoniae strain YZ22PK089

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OK017_RS03960 Protein ID WP_002916310.1
Coordinates 798139..798549 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OK017_RS03955 Protein ID WP_002916312.1
Coordinates 797892..798158 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK017_RS03930 (793048) 793048..794481 - 1434 WP_064152027.1 6-phospho-beta-glucosidase -
OK017_RS03935 (794600) 794600..795328 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OK017_RS03940 (795378) 795378..795689 + 312 WP_064152028.1 N(4)-acetylcytidine aminohydrolase -
OK017_RS03945 (795853) 795853..796512 + 660 WP_002916317.1 hemolysin III family protein -
OK017_RS03950 (796663) 796663..797646 - 984 WP_064152029.1 tRNA-modifying protein YgfZ -
OK017_RS03955 (797892) 797892..798158 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OK017_RS03960 (798139) 798139..798549 + 411 WP_002916310.1 protein YgfX Toxin
OK017_RS03965 (798556) 798556..799077 - 522 WP_004144730.1 flavodoxin FldB -
OK017_RS03970 (799178) 799178..800074 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OK017_RS03975 (800097) 800097..800810 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OK017_RS03980 (800816) 800816..802549 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T263331 WP_002916310.1 NZ_CP110170:798139-798549 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT263331 WP_002916312.1 NZ_CP110170:797892-798158 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References