Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 167906..168549 Replicon plasmid pYZ22CS094_1
Accession NZ_CP110168
Organism Klebsiella pneumoniae strain YZ22CS094

Toxin (Protein)


Gene name vagD Uniprot ID A0A155IU92
Locus tag OK019_RS27225 Protein ID WP_000754567.1
Coordinates 168133..168549 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A853H7M9
Locus tag OK019_RS27220 Protein ID WP_001261275.1
Coordinates 167906..168136 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK019_RS27205 163736..165328 + 1593 WP_227591599.1 hypothetical protein -
OK019_RS27215 166628..167653 + 1026 WP_227591611.1 nuclease domain-containing protein -
OK019_RS27220 167906..168136 + 231 WP_001261275.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OK019_RS27225 168133..168549 + 417 WP_000754567.1 type II toxin-antitoxin system VapC family toxin Toxin
OK019_RS27230 168730..169749 - 1020 WP_064160291.1 fimbrial protein -
OK019_RS27235 169770..172163 - 2394 WP_064163930.1 fimbria/pilus outer membrane usher protein -
OK019_RS27240 172175..172870 - 696 WP_064160295.1 molecular chaperone -
OK019_RS27245 172929..173498 - 570 WP_064160296.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrB4 / blaDHA-1 / sul1 / armA / msr(E) / mph(E) / aph(3')-Ia / aph(3'')-Ib / aph(6)-Id / aph(4)-Ia / aac(3)-IVa / sul3 / ant(3'')-Ia / cmlA1 / aadA2 pla 1..262096 262096


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15108.61 Da        Isoelectric Point: 8.5403

>T263327 WP_000754567.1 NZ_CP110168:168133-168549 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8707.72 Da        Isoelectric Point: 4.3410

>AT263327 WP_001261275.1 NZ_CP110168:167906-168136 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155IU92

Antitoxin

Source ID Structure
AlphaFold DB A0A853H7M9

References