Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 55493..56403 Replicon plasmid pYZ22CS094_1
Accession NZ_CP110168
Organism Klebsiella pneumoniae strain YZ22CS094

Toxin (Protein)


Gene name - Uniprot ID R4YBC5
Locus tag OK019_RS26650 Protein ID WP_004144067.1
Coordinates 55933..56403 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6A8PHD0
Locus tag OK019_RS26645 Protein ID WP_023287184.1
Coordinates 55493..55936 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK019_RS26630 50792..51973 + 1182 WP_023287181.1 hypothetical protein -
OK019_RS26635 51970..54198 + 2229 WP_032430744.1 ThiF family adenylyltransferase -
OK019_RS26640 54251..55392 + 1142 Protein_51 translesion error-prone DNA polymerase V subunit UmuC -
OK019_RS26645 55493..55936 + 444 WP_023287184.1 DUF2384 domain-containing protein Antitoxin
OK019_RS26650 55933..56403 + 471 WP_004144067.1 RES family NAD+ phosphorylase Toxin
OK019_RS26655 56490..56810 + 321 Protein_54 IS5/IS1182 family transposase -
OK019_RS26660 56843..57811 + 969 WP_074423483.1 IS5 family transposase -
OK019_RS26665 58150..59361 - 1212 WP_017901247.1 M24 family metallopeptidase -
OK019_RS26670 59448..60401 - 954 WP_020481021.1 LysR substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrB4 / blaDHA-1 / sul1 / armA / msr(E) / mph(E) / aph(3')-Ia / aph(3'')-Ib / aph(6)-Id / aph(4)-Ia / aac(3)-IVa / sul3 / ant(3'')-Ia / cmlA1 / aadA2 pla 1..262096 262096


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17573.83 Da        Isoelectric Point: 4.5152

>T263326 WP_004144067.1 NZ_CP110168:55933-56403 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16522.84 Da        Isoelectric Point: 10.3013

>AT263326 WP_023287184.1 NZ_CP110168:55493-55936 [Klebsiella pneumoniae]
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A384IED8

Antitoxin

Source ID Structure
AlphaFold DB A0A6A8PHD0

References