Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4768735..4769251 Replicon chromosome
Accession NZ_CP110167
Organism Klebsiella pneumoniae strain YZ22CS094

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OK019_RS23650 Protein ID WP_004178374.1
Coordinates 4768735..4769019 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OK019_RS23655 Protein ID WP_002886901.1
Coordinates 4769009..4769251 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK019_RS23625 (4764130) 4764130..4764393 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
OK019_RS23630 (4764523) 4764523..4764696 + 174 WP_032412860.1 hypothetical protein -
OK019_RS23635 (4764699) 4764699..4765442 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OK019_RS23640 (4765799) 4765799..4767937 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OK019_RS23645 (4768267) 4768267..4768731 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OK019_RS23650 (4768735) 4768735..4769019 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OK019_RS23655 (4769009) 4769009..4769251 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OK019_RS23660 (4769329) 4769329..4771239 - 1911 WP_004152270.1 PRD domain-containing protein -
OK019_RS23665 (4771262) 4771262..4772416 - 1155 WP_002886900.1 lactonase family protein -
OK019_RS23670 (4772483) 4772483..4773223 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T263323 WP_004178374.1 NZ_CP110167:c4769019-4768735 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT263323 WP_002886901.1 NZ_CP110167:c4769251-4769009 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References