Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4642936..4643746 Replicon chromosome
Accession NZ_CP110167
Organism Klebsiella pneumoniae strain YZ22CS094

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag OK019_RS23095 Protein ID WP_004178461.1
Coordinates 4642936..4643469 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag OK019_RS23100 Protein ID WP_002887278.1
Coordinates 4643480..4643746 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK019_RS23090 (4641767) 4641767..4642888 + 1122 WP_004186850.1 cupin domain-containing protein -
OK019_RS23095 (4642936) 4642936..4643469 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
OK019_RS23100 (4643480) 4643480..4643746 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
OK019_RS23105 (4643849) 4643849..4645282 - 1434 WP_004186848.1 Cu(+)/Ag(+) sensor histidine kinase -
OK019_RS23110 (4645272) 4645272..4645955 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
OK019_RS23115 (4646128) 4646128..4647513 + 1386 WP_064152126.1 efflux transporter outer membrane subunit -
OK019_RS23120 (4647531) 4647531..4647875 + 345 WP_064152125.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T263322 WP_004178461.1 NZ_CP110167:c4643469-4642936 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT263322 WP_002887278.1 NZ_CP110167:c4643746-4643480 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References