Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2590619..2592207 Replicon chromosome
Accession NZ_CP110167
Organism Klebsiella pneumoniae strain YZ22CS094

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag OK019_RS12795 Protein ID WP_002904792.1
Coordinates 2590619..2591941 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag OK019_RS12800 Protein ID WP_002904790.1
Coordinates 2591941..2592207 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK019_RS12780 (2585675) 2585675..2588176 + 2502 WP_032433099.1 fimbria/pilus outer membrane usher protein -
OK019_RS12785 (2588164) 2588164..2589168 + 1005 WP_032433097.1 fimbrial protein -
OK019_RS12790 (2589310) 2589310..2590602 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OK019_RS12795 (2590619) 2590619..2591941 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
OK019_RS12800 (2591941) 2591941..2592207 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OK019_RS12805 (2592593) 2592593..2592919 - 327 WP_002904788.1 hydroxyisourate hydrolase -
OK019_RS12810 (2592916) 2592916..2593416 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OK019_RS12815 (2593394) 2593394..2594773 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
OK019_RS12820 (2595119) 2595119..2596273 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OK019_RS12825 (2596254) 2596254..2597177 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T263320 WP_002904792.1 NZ_CP110167:c2591941-2590619 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT263320 WP_002904790.1 NZ_CP110167:c2592207-2591941 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References