Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 806543..807200 Replicon chromosome
Accession NZ_CP110167
Organism Klebsiella pneumoniae strain YZ22CS094

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OK019_RS04035 Protein ID WP_002916310.1
Coordinates 806790..807200 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OK019_RS04030 Protein ID WP_002916312.1
Coordinates 806543..806809 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK019_RS04005 (801699) 801699..803132 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
OK019_RS04010 (803251) 803251..803979 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OK019_RS04015 (804029) 804029..804340 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
OK019_RS04020 (804504) 804504..805163 + 660 WP_002916317.1 hemolysin III family protein -
OK019_RS04025 (805314) 805314..806297 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OK019_RS04030 (806543) 806543..806809 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OK019_RS04035 (806790) 806790..807200 + 411 WP_002916310.1 protein YgfX Toxin
OK019_RS04040 (807207) 807207..807728 - 522 WP_004144730.1 flavodoxin FldB -
OK019_RS04045 (807829) 807829..808725 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OK019_RS04050 (808748) 808748..809461 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OK019_RS04055 (809467) 809467..811200 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T263315 WP_002916310.1 NZ_CP110167:806790-807200 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT263315 WP_002916312.1 NZ_CP110167:806543-806809 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References