Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 87438..88081 Replicon plasmid unnamed1
Accession NZ_CP110161
Organism Klebsiella pneumoniae strain YZ22CS089

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag OMD38_RS27320 Protein ID WP_285806461.1
Coordinates 87438..87854 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag OMD38_RS27325 Protein ID WP_001261276.1
Coordinates 87851..88081 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD38_RS27300 83455..83676 - 222 Protein_86 GNAT family N-acetyltransferase -
OMD38_RS27305 83710..84678 + 969 WP_013815099.1 IS5-like element IS903B family transposase -
OMD38_RS27310 84773..85447 + 675 WP_285806459.1 fimbrial protein -
OMD38_RS27320 87438..87854 - 417 WP_285806461.1 type II toxin-antitoxin system VapC family toxin Toxin
OMD38_RS27325 87851..88081 - 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OMD38_RS27330 88334..90910 - 2577 WP_285806462.1 nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 - 1..239545 239545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15049.55 Da        Isoelectric Point: 9.2957

>T263311 WP_285806461.1 NZ_CP110161:c87854-87438 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTAIRIAQRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT263311 WP_001261276.1 NZ_CP110161:c88081-87851 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References