Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5377660..5378285 Replicon chromosome
Accession NZ_CP110160
Organism Klebsiella pneumoniae strain YZ22CS089

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OMD38_RS26505 Protein ID WP_002882817.1
Coordinates 5377660..5378043 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OMD38_RS26510 Protein ID WP_004150355.1
Coordinates 5378043..5378285 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD38_RS26490 (5375026) 5375026..5375928 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OMD38_RS26495 (5375925) 5375925..5376560 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OMD38_RS26500 (5376557) 5376557..5377486 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OMD38_RS26505 (5377660) 5377660..5378043 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OMD38_RS26510 (5378043) 5378043..5378285 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OMD38_RS26515 (5378490) 5378490..5379407 + 918 WP_004181612.1 alpha/beta hydrolase -
OMD38_RS26520 (5379421) 5379421..5380362 - 942 WP_285806404.1 fatty acid biosynthesis protein FabY -
OMD38_RS26525 (5380407) 5380407..5380844 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OMD38_RS26530 (5380841) 5380841..5381701 - 861 WP_004146232.1 virulence factor BrkB family protein -
OMD38_RS26535 (5381695) 5381695..5382294 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T263308 WP_002882817.1 NZ_CP110160:c5378043-5377660 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT263308 WP_004150355.1 NZ_CP110160:c5378285-5378043 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References