Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5063775..5065456 Replicon chromosome
Accession NZ_CP110160
Organism Klebsiella pneumoniae strain YZ22CS089

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag OMD38_RS25055 Protein ID WP_004178299.1
Coordinates 5063775..5064692 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag OMD38_RS25060 Protein ID WP_004177809.1
Coordinates 5064698..5065456 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD38_RS25035 (5059081) 5059081..5060601 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
OMD38_RS25040 (5060598) 5060598..5061596 + 999 WP_002885172.1 ribose ABC transporter permease -
OMD38_RS25045 (5061627) 5061627..5062568 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OMD38_RS25050 (5062643) 5062643..5063650 + 1008 WP_004178300.1 carbohydrate kinase family protein -
OMD38_RS25055 (5063775) 5063775..5064692 - 918 WP_004178299.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OMD38_RS25060 (5064698) 5064698..5065456 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OMD38_RS25065 (5065542) 5065542..5066270 - 729 WP_004178298.1 response regulator transcription factor -
OMD38_RS25070 (5066543) 5066543..5068690 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
OMD38_RS25075 (5068687) 5068687..5068830 - 144 WP_022631365.1 hypothetical protein -
OMD38_RS25080 (5069268) 5069268..5069954 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34649.06 Da        Isoelectric Point: 5.4707

>T263307 WP_004178299.1 NZ_CP110160:c5064692-5063775 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT263307 WP_004177809.1 NZ_CP110160:c5065456-5064698 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References