Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4908079..4908595 Replicon chromosome
Accession NZ_CP110160
Organism Klebsiella pneumoniae strain YZ22CS089

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OMD38_RS24265 Protein ID WP_004178374.1
Coordinates 4908079..4908363 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OMD38_RS24270 Protein ID WP_002886901.1
Coordinates 4908353..4908595 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD38_RS24240 (4903563) 4903563..4903826 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
OMD38_RS24245 (4903956) 4903956..4904129 + 174 WP_032408826.1 hypothetical protein -
OMD38_RS24250 (4904132) 4904132..4904875 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OMD38_RS24255 (4905232) 4905232..4907370 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OMD38_RS24260 (4907611) 4907611..4908075 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OMD38_RS24265 (4908079) 4908079..4908363 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OMD38_RS24270 (4908353) 4908353..4908595 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OMD38_RS24275 (4908673) 4908673..4910583 - 1911 WP_004178373.1 PRD domain-containing protein -
OMD38_RS24280 (4910606) 4910606..4911760 - 1155 WP_004178372.1 lactonase family protein -
OMD38_RS24285 (4911827) 4911827..4912567 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T263306 WP_004178374.1 NZ_CP110160:c4908363-4908079 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT263306 WP_002886901.1 NZ_CP110160:c4908595-4908353 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References