Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2712624..2714212 Replicon chromosome
Accession NZ_CP110160
Organism Klebsiella pneumoniae strain YZ22CS089

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OMD38_RS13525 Protein ID WP_004179815.1
Coordinates 2712624..2713946 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OMD38_RS13530 Protein ID WP_004176198.1
Coordinates 2713946..2714212 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD38_RS13510 (2707680) 2707680..2710181 + 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -
OMD38_RS13515 (2710169) 2710169..2711173 + 1005 WP_004179822.1 fimbrial protein -
OMD38_RS13520 (2711315) 2711315..2712607 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OMD38_RS13525 (2712624) 2712624..2713946 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
OMD38_RS13530 (2713946) 2713946..2714212 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OMD38_RS13535 (2714478) 2714478..2714804 - 327 WP_002904788.1 hydroxyisourate hydrolase -
OMD38_RS13540 (2714801) 2714801..2715301 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OMD38_RS13545 (2715279) 2715279..2716658 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
OMD38_RS13550 (2717004) 2717004..2718158 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OMD38_RS13555 (2718139) 2718139..2719062 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T263302 WP_004179815.1 NZ_CP110160:c2713946-2712624 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT263302 WP_004176198.1 NZ_CP110160:c2714212-2713946 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References