Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 2933..3455 Replicon plasmid unnamed3
Accession NZ_CP110156
Organism Klebsiella pneumoniae strain YZ22CS088

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag OMD36_RS28480 Protein ID WP_000220561.1
Coordinates 3174..3455 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag OMD36_RS28475 Protein ID WP_000121743.1
Coordinates 2933..3184 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD36_RS28470 (859) 859..1698 - 840 WP_001352874.1 replication initiation protein -
OMD36_RS28475 (2933) 2933..3184 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
OMD36_RS28480 (3174) 3174..3455 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OMD36_RS28485 (3805) 3805..4320 + 516 WP_001025387.1 J domain-containing protein -
OMD36_RS28490 (4394) 4394..4942 + 549 WP_001178641.1 hypothetical protein -
OMD36_RS28495 (4951) 4951..5220 + 270 WP_001006718.1 hypothetical protein -
OMD36_RS28500 (5210) 5210..5452 + 243 WP_000008708.1 hypothetical protein -
OMD36_RS28505 (5585) 5585..6289 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
OMD36_RS28510 (6295) 6295..6435 + 141 WP_001044210.1 hypothetical protein -
OMD36_RS28515 (6921) 6921..7658 + 738 WP_001446887.1 recombinase family protein -
OMD36_RS28520 (7655) 7655..7879 + 225 WP_000743213.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid floR - 1..29087 29087


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T263294 WP_000220561.1 NZ_CP110156:3174-3455 [Klebsiella pneumoniae]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT263294 WP_000121743.1 NZ_CP110156:2933-3184 [Klebsiella pneumoniae]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References