Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 132801..133552 Replicon plasmid unnamed1
Accession NZ_CP110154
Organism Klebsiella pneumoniae strain YZ22CS088

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag OMD36_RS27560 Protein ID WP_014386536.1
Coordinates 132801..133283 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag OMD36_RS27565 Protein ID WP_004902250.1
Coordinates 133274..133552 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD36_RS27540 129200..129847 - 648 WP_014386537.1 EcsC family protein -
OMD36_RS27545 129874..130629 - 756 WP_004902235.1 DUF2971 domain-containing protein -
OMD36_RS27550 130730..131122 - 393 WP_032442757.1 hypothetical protein -
OMD36_RS27555 131227..131766 - 540 WP_004902239.1 hypothetical protein -
OMD36_RS27560 132801..133283 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
OMD36_RS27565 133274..133552 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
OMD36_RS27570 133671..133883 - 213 WP_004902255.1 hypothetical protein -
OMD36_RS27575 133991..134332 - 342 WP_004902257.1 hypothetical protein -
OMD36_RS27580 135162..135620 - 459 WP_014386535.1 hypothetical protein -
OMD36_RS27585 136874..137758 + 885 WP_004186900.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 - 1..239545 239545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T263292 WP_014386536.1 NZ_CP110154:c133283-132801 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT263292 WP_004902250.1 NZ_CP110154:c133552-133274 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References