Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5379855..5380480 Replicon chromosome
Accession NZ_CP110153
Organism Klebsiella pneumoniae strain YZ22CS088

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OMD36_RS26510 Protein ID WP_002882817.1
Coordinates 5379855..5380238 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OMD36_RS26515 Protein ID WP_004150355.1
Coordinates 5380238..5380480 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD36_RS26495 (5377221) 5377221..5378123 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OMD36_RS26500 (5378120) 5378120..5378755 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OMD36_RS26505 (5378752) 5378752..5379681 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OMD36_RS26510 (5379855) 5379855..5380238 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OMD36_RS26515 (5380238) 5380238..5380480 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OMD36_RS26520 (5380685) 5380685..5381602 + 918 WP_004181612.1 alpha/beta hydrolase -
OMD36_RS26525 (5381616) 5381616..5382557 - 942 WP_285806404.1 fatty acid biosynthesis protein FabY -
OMD36_RS26530 (5382602) 5382602..5383039 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OMD36_RS26535 (5383036) 5383036..5383896 - 861 WP_004146232.1 virulence factor BrkB family protein -
OMD36_RS26540 (5383890) 5383890..5384489 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T263288 WP_002882817.1 NZ_CP110153:c5380238-5379855 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT263288 WP_004150355.1 NZ_CP110153:c5380480-5380238 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References