Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 851570..852227 Replicon chromosome
Accession NZ_CP110153
Organism Klebsiella pneumoniae strain YZ22CS088

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OMD36_RS04235 Protein ID WP_002916310.1
Coordinates 851817..852227 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OMD36_RS04230 Protein ID WP_002916312.1
Coordinates 851570..851836 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD36_RS04205 (846726) 846726..848159 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
OMD36_RS04210 (848278) 848278..849006 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OMD36_RS04215 (849056) 849056..849367 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
OMD36_RS04220 (849531) 849531..850190 + 660 WP_002916317.1 hemolysin III family protein -
OMD36_RS04225 (850341) 850341..851324 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
OMD36_RS04230 (851570) 851570..851836 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OMD36_RS04235 (851817) 851817..852227 + 411 WP_002916310.1 protein YgfX Toxin
OMD36_RS04240 (852234) 852234..852755 - 522 WP_064159432.1 flavodoxin FldB -
OMD36_RS04245 (852856) 852856..853752 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OMD36_RS04250 (853775) 853775..854488 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OMD36_RS04255 (854494) 854494..856227 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T263277 WP_002916310.1 NZ_CP110153:851817-852227 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT263277 WP_002916312.1 NZ_CP110153:851570-851836 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References