Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5122987..5123612 Replicon chromosome
Accession NZ_CP110150
Organism Klebsiella pneumoniae strain YZ22CS072

Toxin (Protein)


Gene name vapC Uniprot ID A0A483GDF6
Locus tag OK018_RS24950 Protein ID WP_004187928.1
Coordinates 5122987..5123370 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OK018_RS24955 Protein ID WP_004150355.1
Coordinates 5123370..5123612 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK018_RS24935 (5120353) 5120353..5121255 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OK018_RS24940 (5121252) 5121252..5121887 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OK018_RS24945 (5121884) 5121884..5122813 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OK018_RS24950 (5122987) 5122987..5123370 - 384 WP_004187928.1 type II toxin-antitoxin system VapC family toxin Toxin
OK018_RS24955 (5123370) 5123370..5123612 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OK018_RS24960 (5123806) 5123806..5124723 + 918 WP_032437488.1 alpha/beta hydrolase -
OK018_RS24965 (5124737) 5124737..5125678 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OK018_RS24970 (5125723) 5125723..5126160 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OK018_RS24975 (5126157) 5126157..5127017 - 861 WP_004146232.1 virulence factor BrkB family protein -
OK018_RS24980 (5127011) 5127011..5127610 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14407.64 Da        Isoelectric Point: 7.3178

>T263271 WP_004187928.1 NZ_CP110150:c5123370-5122987 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT263271 WP_004150355.1 NZ_CP110150:c5123612-5123370 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GDF6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References